NEPTUNE

Information for Patients and Families

What is Nephrotic Syndrome?

Nephrotic Syndrome occurs when there is a malfunction in the kidney’s filtering system (glomeruli) causing protein in the blood to leak into the urine (proteinuria). Nephrotic syndrome may be caused by many conditions, most commonly focal segmental glomerulosclerosis (FSGS), minimal change disease (MCD), and membranous nephropathy (MN).

What are some of the symptoms of Nephrotic Syndrome?

Nephrotic syndrome causes excessive loss of protein in the urine which may lead to:

  • Swelling in parts of the body (edema) most visible in the head, hands, feet and abdomen.

  • Low level of protein in the blood (hypoalbuminemia).
  • High blood cholesterol

Learn more about specific Nephrotic Syndromes: