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5510: VCRC Genetic Repository One-Time DNA Study

Status: Recruiting

Summary:

Please Note: The Rare Diseases Clinical Research Network will make every effort to enroll all the patients we can, but we cannot make any guarantees that we will be able to enroll everyone in a particular study who wants to participate.

For Diseases

Eosinophilic granulomatosis with polyangiitis (Churg-Strauss, EGPA), giant cell arteritis (GCA), microscopic polyangiitis (MPA), polyarteritis nodosa (PAN), Takayasu's arteritis (TAK), and Granulomatosis with polyangiitis (Wegener's, GPA).

Background

The purpose of this study is to identify genes that increase the risk of developing vasculitis, a group of severe diseases that feature inflammation of blood vessels. Results of these studies will provide researchers in vasculitis with insight into the causes of these diseases and generate new ideas for diagnostic tests and therapies, and will be of great interest to the larger communities of researchers investigating vasculitis and other autoimmune, inflammatory, and vascular diseases.

About this Study

A total of 1,300 subjects with EGPA, GCA, MPA, PAN, TAK, and GPA will be enrolled in this study. Study subjects will only be seen once for this research study.

For this visit, you will be asked to:

  • Discuss your medical history and disease
  • Give blood (approximately1 tablespoon) for DNA collection

Target Enrollment:

To be eligible to participate, you must:

  • Be an individual with a confirmed diagnosis of one of the following:
    • Eosinophilic granulomatosis with polyangiitis (Churg-Strauss, EGPA)
    • Giant Cell Arteritis
    • Microscopic Polyangiitis
    • polyarteritis nodosa
    • Takayasu's arteritis
    • Granulomatosis with polyangiitis (Wegener's, GPA).

You are not eligible to participate if:

  • You are unwilling to provide blood for DNA collection
  • Are enrolled in another VCRC protocol (because we will already have collected your DNA)

How to Participate:

In order to participate in a study, you must personally contact the study coordinator of any of the participating institutions by phone or by e-mail. Please use the information below to inquire about participation.

United States

California

  • Cedars-Sinai Medical Center, Los Angeles
    Heather Zmyewski
    Clinical Research Coordinator
    E-mail: Heather.Zmyewski@cshs.org
    Phone: 310-360-9197

  • University of California, San Francisco
    Sharon A. Chung, MD MAS
    E-mail Sharon.chung@ucsf.edu
    Phone: 415-514-1673

Massachusetts

  • Boston University School of Medicine, Boston
    Naomi Amudala
    Study Coordinator
    E-mail: namudala@bu.edu
    Phone: 617-414-2512

Michigan

  • University of Michigan, Ann Arbor
    Angie Theil
    Study Coordinator
    Email: atheil@umich.edu
    Phone: 734-232-5920

Minnesota

New York

  • Hospital for Special Surgery, New York
    Daniele Lerner
    Research Assistant
    E-mail: lernerd@hss.edu
    Phone: 646-714-6302

Ohio

  • Cleveland Clinic, Cleveland
    Katie Gartner
    E-mail: gartnek@ccf.org
    Phone: 216-445-1397

Pennsylvania

  • University of Pennsylvania, Philadelphia
    Brian Rice
    Study Coordinator
    E-mail: brian.rice@uphs.upenn.edu
    Phone: 215-614-4407

  • University of Pittsburgh, Pittsburgh
    Dawn McBride, RN, BA
    Study Coordinator
    E-mail: dlmc@pitt.edu
    Phone: 412-586-3545

Utah

Canada

Ontario

  • St. Joseph's Healthcare, Hamilton
    Sandra Messier, RCT
    Research Coordinator
    E-mail: smessier@stjosham.on.ca
    Phone: 905-522-1155 Ext. 35873

  • University of Toronto Mount Sinai Hospital, Toronto
    Samyukta Jagadeesh
    Study Coordinator
    E-mail: sjagadeesh@mtsinai.on.ca
    Phone: 416-586-8616

    Deborah Weber, RN, CCRC
    Study Coordinator
    E-mail: dweber@mtsinai.on.ca