The Rare Genetic Steroid Disorders Consortium
Participating Clinical Centers

Mount Sinai School of Medicine

Maria New, M.D.
Professor of Pediatrics
Pediatric Endocrinology
Director, Adrenal Steroid Disorders Program

The Mount Sinai School of Medicine
One Gustave L. Levy Place, Box 1198
New York NY 10029-6574
Tel: (212) 241-7847
Fax: (212) 241-5405
E-mail: maria.new@mssm.edu

Susan C. Baker, Ph.D.

Madeleine D. Harbison, M.D.

Arlene Mercado, MD
Senior Research Fellow / Genetic Counseling

Jihad S. Obeid, MD

Robert C. Wilson, Ph.D.

Contact Information:

Contact Information:

Research & Academic: (212) 241-7847

Clinic Appointments: (212) 241-8210

About Us:

The Adrenal Steroid Disorders Program at Mount Sinai School of Medicine studies and treats a variety of disorders resulting from disruption of adrenal steroid metabolism including congenital adrenal hyperplasia, forms of low renin hypertension and intersex conditions. The Program Director is Dr. Maria I New, whose work in the area of steroid disorders spans 50 years.

Dr. New has been honored for her work by election to the National Academy of Sciences and was recently inducted into the National Institute of Child Health and Human Development Hall of Honor.

Our laboratory, under the direction of Robert C. Wilson, PhD, performs DNA analysis and hormone testing, allowing precise diagnosis and treatment of the disorders listed above.

Useful Links

Mount Sinai School of Medicine

Adrenal Steroid Disorders Program at Mount Sinai School of Medicine: under construction

Web site for Dr. Maria New (www.marianew.com)

Trials Active at This Site :

5601 - The Natural History of Rare Genetic Steroid Disorders: Apparent Mineralocorticoid Excess (AME)

5607 - Modifier Genes in 21-Hydroxylase Deficiency

5610 - Long-Term Outcome in Offspring and Mothers of Dexamethasone-Treated Pregnancies at Risk for Classical Congenital Adrenal Hyperplasia Owing to 21-Hydroxylase Deficiency

5611 - Potential Modulatory Role of Osteoprotegerin in Bone Metabolism of Patients with 21-Hydroxylase Deficiency

Publications:

The following have been selected from over 500 publications. For a complete list please visit: www.marianew.com

New MI, Wilson RC. Inaugural Article: Steroid disorders in children: congenital adrenal hyperplasia and apparent mineralocorticoid excess. Proc Natl Acad Sci 96:12790-12797, 1999.

Speiser PW, Dupont B, Rubinstein P, Piazza A, Kastelan A. New MI: High frequency of nonclassical steroid 21 hydroxylase deficiency. Am J Hum Genet, 37:650-667, 1985.

Tannin GM, Agarwal AK, Monder C, New MI, White PC: The human gene for 11b-hydroxysteroid dehydrogenase. Structure, tissue distribution and chromosomal localization. J Biol Chem 266: 16653-16658, 1991.

Curnow KM, Slutsker L, Vitek J, Cole T, Speiser PW, New MI, White PC, Pascoe L: Mutations in the CYP11B1 gene causing congenital adrenal hyperplasia and hypertension cluster in exons 6, 7, and 8. Proc Natl Acad Sci USA 90:4552-4556, 1993.

New MI, Carlson A, Obeid J, Marshall I, Goseco A, Cabrera M, Lin-Su K, Putnam AS, Wei JQ, Wilson RC. Extensive Personal Experience: Prenatal Diagnosis for Congenital Adrenal Hyperplasia in 532 Pregnancies. J Clin Endocrinol Metab , 86 (12):5651-5657, 2001.

Lin-Su K, Vogiatzi MG, Marshall I, Harbison MD, Macapagal MC, Betensky B, Tansil S, New MI.  Treatment with Growth Hormone and LHRH Analogue Improves Final Adult Height in Children with Congenital Adrenal Hyperplasia.  J Clin Endocrinol Metab.  (Accepted 2005).

Chemaitilly W, Betensky BP, Marshall I, Wei JQ, Wilson RC, New MI.  The Natural History and Genotype-Phenotype Nonconcordance of HLA Identical Siblings with the Same Mutations of the 21-Hydroxylase Gene.  J Pediatr Endocrinol Metab .  18(2) 2005.

Meyer-Bahlburg HFL, Dolezal C, Baker SW, Carlson AD, Obeid JS, New MI. Cognitive and motor development of children with and without congenital adrenal hyperplasia after early-prenatal dexamethasone. J Clin Endocrinol Metab.  89(2):610-614, 2004.

Cerame BI, Newfield RS, Pascoe L, Curnow KM, Nimkarn S, Roe TF, New MI, Wilson RC:  Prenatal diagnosis and treatment of 11 b -hydroxylase deficiency congenital adrenal hyperplasia resulting in normal female genitalia. J Clin Endocrinol Metab 84:3129-3134, 1999.

Cabrera M, Vogiatzi MG, New  MI. Long-term outcome in adult males with classic congenital adrenal hyperplasia. J Clin Endocrinol Metab 86(7): 3070-3078,2001.

Wilson RC, Dave-Sharma S, Wei J-Q, Obeyesekere VR, Li K, Ferrari P, Krozowski ZS, Shackleton CHL, Bradlow L, Wiens T, New MI:  A new genetic defect resulting in mild low-renin hypertension.  Proc Natl Acad Sci USA 95: 10200-10205, 1998.

Dave-Sharma S, Wilson RC, Harbison MD, Newfield R, Razzaghy-Azar, Krozowski ZS, Funder JW, Shackleton CHL, Bradlow HL, Wei J-Q, Hertecant J, Moran A, Neiberger RE, Balfe JW, Fattah A, Daneman D, Akkurt HI, DeSantis C, New MI:  Extensive personal experience:  examination of genotype and phenotype relationships in 14 patients with apparent-mineralocorticoid excess.  J Clin Endocrinol Metab 83: 2244-2254, 1998.