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National Institute of Allergy and Infectious Diseases |
Dr. Kenneth Olivier, MD, MPH
Principal Investigator
Immunopathogenesis Section
Laboratory of Clinical Infectious Diseases
National Institute of Allergy and Infectious Diseases
Bldg 10, 11N228
Bethesda, MD 20892
Contact Information:
Reginald Claypool, CAPT, USPHS
Protocol Coordinator
Laboratory of Clinical Infectious Diseases
9000 Rockville Pike
Bldg 10, 11N-234
Bethesda, MD 20892-1888
301-402-7831
Fax: 301-480-1697
rclaypool@niaid.nih.gov
Current Studies:
5901: Longitudinal Study of Primary Ciliary Dyskinesia: Participants 5-18 Years of Age
5902: Rare Genetic Disorders of the Airways: Cross-sectional Comparison of Clinical Features, and Development of Novel Screening and Genetic Tests
5904: Cross Sectional Characterization of Idiopathic Bronchiectasis
About Us
The National Institute of Allergy and Infectious Diseases
The National Institute of Allergy and Infectious Diseases (NIAID) conducts and supports basic and applied research to better understand, treat, and ultimately prevent infectious, immunologic, and allergic diseases. For more than 50 years, NIAID research has led to new therapies, vaccines, diagnostic tests, and other technologies that have improved the health of millions of people in the United States and around the world.
Laboratory of Clinical Infectious Diseases
The Laboratory of Clinical Infectious Diseases (LCID), one of 18 Labs/Branches within the NIAID Division of Intramural Research on the Bethesda campus, conducts clinical and basic research in immunological disorders and human infectious diseases, focusing on bacterial and mycobacterial infections, fungal infections, herpes simplex virus infections, and primary immunodeficiences associated with the incidence and severity of infection in humans. With an emphasis on applied research and patient care, LCID is committed to developing a comprehensive understanding of the natural history, pathogenesis, and management of immunologic and infectious diseases.
In particular, LCID's Immunopathogenesis Section studies chronic granulomatous disease, hyper-IgE syndromes, and tuberculous and nontuberculous mycobacterial infections, including the symptoms, pathogenesis, and treatment of pulmonary nontuberculous mycobacterial disease. While nontuberculous mycobacteria are ubiquitous environmental organisms that rarely cause disease in humans, a population of individuals with bronchiectasis associated with these organisms has been identified, and a cohort of these individuals is evaluated in an ongoing natural history protocol. Although these individuals display no identifiable systemic immune defects or predisposing conditions, their susceptibility to infection suggests an impairment of host defenses, and these patients with pulmonary nontuberculous mycobacterial disease share many overlapping features with clinical and genetic manifestations of known airways clearance disorders.
As a participating center in the Genetic Disorders of Mucociliary Clearance Consortium, we hope this cross-sectional comparison and study of mucociliary clearance disorders will not only contribute to our understanding of the pathogenesis and natural history of diseases such as variant cystic fibrosis and primary ciliary dyskinesia, but may help us to better define and characterize host infection by organisms such as the nontuberculous mycobacteria.
Useful Links:
National Institute of Allergy and Infectious Diseases
Laboratory of Clinical Infectious Diseases
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