CLiC Cholestatic Liver Disease Consortium

Mitochondrial Hepatopathies

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Hepatic mDNA depletion

Alpers disease, complex III defect, valproic acid and
acute liver failure

Alpers disease, valproic acid and acute liver failure

Alpers disease, late stage liver lesion

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Alagille Syndrome

Alpha-1 Antitrypsin Deficiency

Bile Acid Synthesis Defects

> Mitochondrial Hepatopathies

PFIC (Progressive Familial Intrahepatic Cholestasis)