Clic Logo Clic - Cholestatic Liver Diesase Consortium

CLiC Cholestatic Liver Disease Consortium

Participaiting Clinical Centers

Texas Children's Hospital

  

Texas Children's Hospital Web Site

Contact Information:

Saul Karpen, MD, Phd
CLiC Site Principal Investigator
E-mail: skarpen@bcm.tmc.edu

Milton J. Finegold, MD
CLiC Pathologist

Kimberly W. Pieplow
CLiC Study Coordinator
E-mail: kkw@bcm.tmc.edu
832.824.3756

About Us:

Useful Links:

Texas Children's Liver Center Information

Texas Children's Liver Center Web Site

Publications:

Balistreri, W.F., Bezerra, J.A., Jansen, P., Karpen, S.J., Shneider, B.L., and Suchy, F.J. Intrahepatic Cholestasis: Summary of an American Association for the Study of Liver Diseases Single-Topic Conference. Hepatology 42 (1):222-235, 2005.

Karpen, Saul J. " Exercising the Nuclear Option to Treat Cholestasis: Car and PXR Lidands". Commentary on article Wagner, M. et al, "CAR and PXR agonists stimulate hepatic bile acid and bilirubin detoxification and elimination pathways in mice". Hepatology 42 (2):267-267, 2005.

Karpen, S.J. Transcriptional regulation of hepatobiliary transporters. In: M. Trauner and P. Jansen, eds. Molecular Pathogenesis of Cholestasis. Georgetown, TX: Eurekah.com/Landes Bioscience and Kluwer Academic/Plenum Publishers, 2004, pp. 96-111.

Kurbegov, A. and Karpen, S.J. Bile formation and cholestasis. In: W.A Walker, O.L. Goulet, R.E. Kleinman, I.R. Sanderson, P.M. Sherman, B.L. Shneider, eds. Pediatric Gastrointestinal Disease, 4 th Edition. Ontario: BC Decker, Inc., 2004, pp. 70-79.

Karpen, S.J. Update on the etiologies and management of neonatal cholestasis. Clin Perinatol 29 :159-180, 2002 (Invited Review).

Karpen, S.J. Nuclear receptor regulation of hepatic function. J Hepatology 36 :832-50, 2002 (Invited Review).

Li, D., T.L. Zimmerman, S. Thevananther, H. Lee, J. Kurie, S.J. Karpen.  IL-1ß mediated suppression of RXR:RAR transaction of the Ntcp promoter is JNK-dependent.  J Biol Chem 277 :31416-31422, 2002.

Thevananther, S., S. Hongdan, D. Li, V. Arjunan, S.S. Awad, S. Wyllie, T.L. Zimmerman, J.A. Goss, S.J. Karpen.  Extracellular ATP activates c-jun N-terminal kinase signaling and cell cycle progression in hepatocytes. Hepatology 39 :393-402, 2004.

Ghose, R., T.L. Zimmerman, S. Thevananther, S.J. Karpen.  Endotoxin leads to rapid nuclear export of hepatic RXRa: A novel mechanism for reduced hepatic gene expression in inflammation. Nucl Recept, 2:4, August, 2004.

Sturm E, R. Havinga, J.F. Baller, H. Wolters, N. van Rooijen, J.A. Kamps, H.J. Verkade, S.J. Karpen,  F. Kuipers. Kupffer cell depletion with liposomal clodronate prevents suppression of Ntcp expression in endotoxin-treated rats.  J Hepatol 42 :102-9, 2005.