What is CLiC?

The Cholestatic Liver Disease Consortium (CLiC) is a collaborative team of doctors, nurses, research coordinators, and patient support organizations throughout the US and UK, working together to improve the lives of children and families dealing with rare Cholestatic Liver Diseases. The goal of the CLiC team is to investigate five genetic causes of intrahepatic cholestasis and to train the next generation of clinical researchers. These five diseases are:

• Alpha-1-antitrypsin (a-1AT) deficiency
• Alagille syndrome (AGS)
• Progressive familial intrahepatic cholestasis (PFIC)
• Bile acid synthesis and metabolism defects
• Mitochondrial hepatopathies

The purpose of this consortium is to provide a way for patients to join with doctors and researchers by participating in research studies. The greater the collaboration between doctors and patients and their families, the more we can learn about cholestatic liver diseases. This important first step is necessary if we are to find new and better treatments. CLiC can help you:

• Obtain helpful information about these diseases
• Stay up to date with new developments
• Become aware of clinical research and clinical trial opportunities
• Connect with patient support groups

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