Kansas University Medical Center

3901 Rainbow Boulevard, MS 4015
Kansas City, Kansas 66160

Contact Information:

Merlin G. Butler, MD, PhD, FFACMG
Professor of Psychiatry, Behavioral Sciences and Pediatrics
E-mail: mbutler4@kumc.edu

Jennifer Roberts
Research Coordinator
Email: jroberts6@kumc.edu
Phone: (913) 588-1871

Current Clinical Studies:

5202: Prader-Willi Syndrome and Early-onset Morbid Obesity Natural History Clinical Protocol

Links:

Kansas University Medical Center

List of Publications:

1. Books

Editor, Genetics of Developmental Disabilities, 1st ed., Taylor & Francis, Boca Raton, FL. pp. 1-912, 2005.

Editor, Management of Prader-Willi Syndrome, 3rd ed., Springer-Verlag Publishers, New York, NY. pp. 1-550, 2006.

2. Selected Peer-reviewed Publications (from a total of over 300)

Butler, M.G. (1990). Prader-Willi syndrome: Current understanding of cause and diagnosis. Am J Med Genet 35:319-332.

Cassidy, S.B., Beaudet, A.L., Knoll, J.H.M., Ledbetter, D.H., Nicholls, R.D., Schwartz, S. & Butler,M.G., (1996). Diagnostic testing for Prader-Willi and Angelman syndromes: Report of the ASHG/ACMG test and technology transfer committee. Am J Med Genet 58:1085-1088.

Sun, Y., Nicholls, R.D., Butler, M.G., Saitoh, S., Hainline, B.E. & Palmer, C.G. (1996). Breakage in the SNRPN locus in a balanced 46,XY,t(15;19) Prader-Willi syndrome patient. Hum Molec Genet 5:517-524.

Ohta, T., Gray, T.A., Rogan, P.K., Buiting, K., Gabriel, J.M., Saitoh, S., Muralidhar, B., Driscoll, D.J., Horsthemke, B., Butler, M.G. & Nicholls, R.D. (1999). Imprinting mutation mechanism in Prader-Willi syndrome represent a new paradigm for genetic disease. Am J Hum Genet 64: 397-413.

Roof, E., Stone, W., MacLean, W., Feurer, I., Thompson, T. & Butler, M.G. (2000). Intellectual characteristics of Prader-Willi syndrome: Comparisons of genetic subtypes. J Intell Disabil Res 44:25-30.

Butler, M.G. & Thompson, T. (2000). Prader-Willi syndrome: Clinical and genetic findings. The Endocrinol 10:35-165.

Dimitropoulos, A., Feurer, I., Butler, M.G., & Thompson, T. (2001). Emergence of compulsive behavioral and tantrums in children with PWS. Am J Ment Retard 106:39-51.

Butler, M.G. (2002). Imprinting disorders: Non-mendelian mechanisms affecting growth. J. Ped. Endo. & Metab. 15:1279-1288.

Bittel, D.C., Kibiryeva, N., Talebizadeh, Z. & Butler, M.G. (2003). Microarray analysis of gene/transcript expression in Prader-Willi syndrome: Deletions vs. UPD. J Med Genet 40:568-574.

Butler, M.G., Bittel, D., Kibieryeva, N., Talebizadeh, Z. & Thompson, T. (2004). Behavioral difference among subjects with Prader-Willi syndrome and Type I or Type II deletion and maternal disomy. Pediatrics 113: 565-573.

Bittel, D.C., Kibiryeva, N., Talebizadeh, Z., Driscoll, D.J., & Butler, M.G. (2005). Microarray analysis of gene/transcript expression in Angelman syndrome: Deletion versus UPD. Genomics 85:85-91.

Bittel, D.C. & Butler, M.G. (2005). Prader-Willi syndrome: clinical genetics, cytogenetics and molecular biology. Expert Rev Molecular Med 7(14):1-20.

Butler, M.G. (2006). Management of obesity in Prader-Willi syndrome. Nat Clin Pract Endocrinol Metab. 2(11):592-593. 

Bittel, D.C., Kibiryeva, N., & Butler, M.G. (2006). Expression of 4 genes between chromosome 15 breakpoints 1 and 2 and behavioral outcomes in Prader-Willi syndrome. Pediatrics 118(4):e1276-1283.

Bittel, D.C., Kibiryeva, N., McNulty, S.G., Driscoll, D.J., Butler, M.G., & White, R. A. (2007). Whole genome microarray analysis of gene expression in an imprinting center deletion mouse model of Prader-Willi syndrome. Am. J. Med. Genet. A. 143(5):422-429.

Holsen, L.M., Zarcone, J.R., Brooks, W.M., Butler, M.G., Thompson, T.I., Ahluwalia, J.S., Nollen, N.G., & Savage, C.R. (2006). Neural mechanisms underlying hyperphagia in Prader-Willi syndrome. Obesity 14:1028-1037.

Butler, M.G., Theodoro, M.F., Bittel, D.C., & Donnelly, J.E. (2007). Energy expenditure and physical activity in Prader-Willi syndrome: Comparison with obese subjects. Am. J. Med. Genet. A.143(5):449-459.

Bittel, D.C., Kibiryeva, N., Sell, S.M., Strong, T.V., & Butler, M.G. (2007). Whole genome microarray analysis of gene expression in Prader-Willi syndrome. Am. J. Med. Genet. A.143(5):430-442.

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