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Autoimmune Autonomic Ganglionopathy
What is autoimmune autonomic ganglionopathy (AAG)?
Autoimmune autonomic ganglionopathy (AAG) is a rare disorder characterized by the presence of autonomic failure in association with specific antibodies directed against a specific receptor of the autonomic ganglia.
Symptoms include:
- Severe orthostatic hypotension (low blood pressure upon standing) that persists for weeks to years
- Fainting
- Constipation
- Urinary retention
- Fixed and dilated pupils
- Dry mouth and eyes
Who gets AAG?
AAG can affect people of all ages and both sexes.
What causes AAG?
The cause of AAG is unknown.
What is the treatment for AAG?
- For mild cases, symptom management is the treatment.
- Many patients remain unable to function normally and disease modifying therapy may help.
- There is no established treatment.
- A therapeutic trial in autoimmune autonomic ganglionopathy is being conducted by the Autonomic Disorders Consortium
